The objective of present investigation was to evaluate the flow, mechanical ,compression and release properties of diclofenac sodium tablets formulated by using binders namely starch ,gelatin ,acacia, polyvinyl pyrrolidone. Granule properties were evaluated using Carr's index and Hausner’s ratio. Based on the Carr's index values the flow properties of binders can be ranked as gelatin>acacia>polyvinyl pyrrolidone>Starch. Granule friability and compressibility properties were determined from %Friability and kawakita parameters. The mechanical properties of the tablets were assessed by using crushing strength, while the drug release properties of the tablets were determined by using Disintegration and dissolution parameters. Based on the dissolution rate, the order of performance of binders was Polyvinyl pyrrolidone>Starch>>Gelatin>Acacia. The flow, compression and dissolution characteristics depend on the binder used. Among all, the granule formulated with polyvinyl pyrrolidone exhibits maximum drug release and satisfies in-vitro quality control requirements.
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